Remember the Fonz? Awesome motorcycle, snazzy leather jacket, ladies man. And the ability to fix any jukebox with a single smack of the fist. What a knock-out punch. Yes, pun intended.
If only there were a way to bottle the restorative power of Fonzie. Well, scientists at the Cancer Institute of New Jersey may have discovered a way, figuratively speaking. Recent work from the lab of Dr. Darren Carpizo, published in the May issue of Cancer Cell, describes the discovery of a drug that selectively kills cancer cells by restoring the function of the tumor suppressor, p53. Continue reading →
Getting back to my roots this week with a story on some good ole cancer research. Or should I say, more advances in the fight against cancer. We are fighting a battle, and just like in any battle, you have to get to the source of the problem. Over half of all cancers share mutations in the p53 gene. p53, which I’ll explain a bit more shortly, has been called the “master watchman” and the “guardian of the genome” – thus mutations in this gene are a major source of cancer problems.
Researchers at the University of Michigan Comprehensive Cancer Center recently presented some exciting work at the 102nd Annual Meeting of the American Association of Cancer Research. This work has not been published yet, but was led by Dr. Shaomeng Wang, whose laboratory website can be found here. They are hard at work developing a chemical compound that will work to block tumor growth by fixing problems with p53.
You always used to hear that we would find a cure for cancer out in the rainforest somewhere…some chemical extracted from an unknown plant that looked more at home on the planet of Pandora than earth. Turns out, the secret cancer fighting compounds have been hiding right under our noses, torturing small children for ages.
That’s right, broccoli possesses a certain cancer-fighting ability, and research published in the January 2011 issue of the American Cancer Society’s Journal of Medicinal Chemistry, led by Dr.Fung-Lung Chung, finally determined what’s going on. Continue reading →